Disturbed leukocyte homeostasis in the blood of Cxcr4^+/1013 mice. (A) Absolute numbers of leukocytes were determined in blood samples. (B-C) Blood samples were stained with indicated mAbs, and the frequencies (mean ± SD, n = 8-13; B) and absolute numbers (C) of total CD4⁺ or CD8⁺ T cells (gated CD3⁺), B cells (gated CD19⁺), and neutrophils (gated Gr1⁺) are shown. (D) Sera total Igs were analyzed. Results of all analyzed littermates are shown (A,C,D). Lines indicate the mean and each circle indicates an individual mouse. (B) Each dot-plot represents one mouse (*P < .05; **P < .005 compared with WT mice).