Figure 1
Results of a meta-analysis of 2 GWAS on 393 cases and 3315 controls. (A) Manhattan plot of the genome-wide results. P values were determined for each SNP based on the meta-analysis of the UC and USC samples. Five SNPs surpassed the genome-wide significance threshold (P value = 5 × 10−8): rs9268542, rs9268528, rs204999, rs2858870, and rs6903608 6p21.3. (B) Regional plot of the 6p21.3 for the combined genome-wide association results. The blue lines represent recombination rates. The previously reported SNP rs6903608 is designated by a diamond; all other SNPs are depicted by circles. (C) Linkage disequilibrium map of the 6p21.3 region (red represents r2 > 0.9).

Results of a meta-analysis of 2 GWAS on 393 cases and 3315 controls. (A) Manhattan plot of the genome-wide results. P values were determined for each SNP based on the meta-analysis of the UC and USC samples. Five SNPs surpassed the genome-wide significance threshold (P value = 5 × 10−8): rs9268542, rs9268528, rs204999, rs2858870, and rs6903608 6p21.3. (B) Regional plot of the 6p21.3 for the combined genome-wide association results. The blue lines represent recombination rates. The previously reported SNP rs6903608 is designated by a diamond; all other SNPs are depicted by circles. (C) Linkage disequilibrium map of the 6p21.3 region (red represents r2 > 0.9).

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