IL-25 enhances the Th2 cytokine production in CSS patients. Th2 (IL-4, IL-5, IL-13) and Th1 (IFN-γ) cytokines production by PBMCs from active CSS patients, atopic patients, and healthy donors after stimulation with anti-CD3/CD28 with or without IL-25 (100 ng/mL) assessed by Luminex in culture supernatants. * P < .05; ** P < .01; *** P < .001. Histograms in each panel are representative of 3 to 4 patients in at least 3 independent experiments.