OS of 626 MM patients. (A) Overall survival (OS) based on high- versus low-risk sIL-6r groups defined by the 81.5 ng/mL cut point. (B) OS based on a combination of the 70-gene GEP model of high- and low-risk disease with the high/low risk conferred by sIL-6r level: a indicates low risk by the 70-gene model and low risk by sIL-6r level; b, low risk by the 70-gene model and high risk by sIL-6r level; c, high risk by the 70-gene model and low risk by sIL-6r level; and d, high risk by the 70-gene model, and high risk by sIL-6r level.