Treatment schema. The single immunization procedure (A) consisted of irradiating a single MF skin lesion on days 1 and 2 (2 Gy each day) along with intratumoral injection of CpG within an hour before the day 1 and after the day 2 RT. CpG was then injected into the same site weekly for an additional 8 doses for a total of 10 doses. From patient 7 (B), a boost immunization was delivered at a distant MF lesion at week 4, and weekly CpG injections were performed at that site until completion of 10 doses. Systemic clinical response was assessed by mSWAT of nonimmunized MF lesions weekly until week 8 and then at week 12. Correlative skin samples were obtained from the immunization site at baseline and week 2.