Impact of additional karyotypic markers at diagnosis and after induction RT-PCR positively on relapse free survival. (A) RFS in entire cohort. (B) CIR of patients who were RT-PCR-positive or -negative at the end of induction. (C) Event-free survival of patients who were RT-PCR–positive or –negative at the end of induction. (D) CIR among good risk cases (WBC < 5 × 109/Lt and platelet count > 20 × 109/Lt at diagnosis) of those who were RT-PCR–positive or –negative at the end of induction. (E) CIR among high-risk group (not fulfilling good risk criteria) who were RT-PCR–positive or –negative at the end of induction. (F) RFS among those who had and those who did not have an additional cytogenetic finding at diagnosis.