Figure 5
Figure 5. Effects of CoQ10 on IgG-APS–induced expression of prothrombotic markers and intracellular pathways. (A) Cell surface TF expression in monocytes treated with IgG-APS or IgG-NHS in the presence or in the absence of CoQ10. Values are means and SEM from 4 independent experiments. (B-D) Representative electrophoretic mobility shift assay and Western blotting results from 4 separate experiments showing, respectively, VEGF and Flt1 expression, p38 MAPK activity, and NF-κB binding activity after the treatments indicated. Significant differences (at P < .05) versus monocytes treated with IgG-NHS (a) and versus IgG-APS–treated cells (b).

Effects of CoQ10 on IgG-APS–induced expression of prothrombotic markers and intracellular pathways. (A) Cell surface TF expression in monocytes treated with IgG-APS or IgG-NHS in the presence or in the absence of CoQ10. Values are means and SEM from 4 independent experiments. (B-D) Representative electrophoretic mobility shift assay and Western blotting results from 4 separate experiments showing, respectively, VEGF and Flt1 expression, p38 MAPK activity, and NF-κB binding activity after the treatments indicated. Significant differences (at P < .05) versus monocytes treated with IgG-NHS (a) and versus IgG-APS–treated cells (b).

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