FdUMP[10] confers a survival benefit equivalent to the combination of Ara-C and Dox. (A) Schema of treatment trial. C57/Bl6 mice were sublethally irradiated to 4.5 Gy and injected with an MLL-ENL and Flt3 ITD syngeneic leukemia. Once engraftment was established by bioluminescence imaging, mice were treated with either saline (S), FdUMP[10] at 300 mg/kg (Fd), 5-FU at 121 mg/kg or Ara-C at 125 mg/kg plus Dox at 3.75 mg/kg (AD) on days 1, 3, 5, and 7. (B) Bioluminescent image of mice on day 6 after treatment. (C) Kaplan-Meier curves for animals treated with Fd, 5-FU, or AD as in panel B.