FdUMP[10] is active against cells expressing adverse prognostic factors. (A) Cytotoxicity assays of murine AML cells that knockdown p53. Cells were exposed to the indicated drugs for 72 hours and then assessed for viability. Viability is shown as percentage of control; error bars represent the SE. (B) Flow cytometry of annexin V assay. Cells expressing the p53 shRNA were exposed to the indicated drug for 48 hours and then labeled with annexin V and propidium iodide (PI). (C) Cytotoxicity assays of murine AML cells expressing either MN1 or BCR-ABL (p210). Cells were exposed to the indicated drugs for 72 hours and then assessed for viability. Viability is shown as percentage of control; error bars represent the SE.