Comparative analysis of NOTCH1 mutations and TP53 disruption. (A-B) Venn diagram illustrating the overlap between NOTCH1 mutations and TP53 disruption by mutations, deletion, or both in the CLL training series (A) and in the CLL validation series (B). Numbers within the red and yellow circles indicate the number of cases harboring NOTCH1 mutations without TP53 disruption (red circle) and cases with TP53 disruption without NOTCH1 mutations (yellow circle). Numbers within the overlaps between circles indicate the number of cases harboring both NOTCH1 mutations and TP53 disruption. (C-D) Kaplan–Meier estimates of OS according to NOTCH1 mutation and TP53 disruption in the CLL training series (n = 309; C) and in the CLL validation series (n = 230; D). Cases with germ line NOTCH1 and TP53 genes (GL) are represented by the blue line. Cases harboring NOTCH1 mutations without TP53 disruption (NOTCH1 M) are represented by the red line. Cases harboring TP53 disruption (TP53 DIS) are represented by the yellow line. Cases harboring both NOTCH1 and TP53 disruption were compiled to cases harboring only TP53 disruption, because of the low number (3 in the training series and 1 in the validation series) of double-mutated cases, and based on a recursive partitioning analysis for risk of death.