Kaplan-Meier estimates of OS from first-line treatment. OS from first line treatment according to NOTCH1 mutation status in CLL treated with fludarabine-based regimens series (n = 113). Cases with germ line NOTCH1 and TP53 genes (GL) are represented by the blue curve. Cases harboring NOTCH1 mutations without TP53 disruption (NOTCH1 M) are represented by the red curve. Cases harboring TP53 disruption without NOTCH1 mutations (TP53 DIS) are represented by the yellow curve. Cases harboring both NOTCH1 mutations and TP53 disruption (NOTCH1 M and TP53 DIS) are represented by the green curve.