Figure 2
Figure 2. Iron parameters are decreased in the Hepc−/−Hif-2αΔint mice compared with Hepc−/− mice. (A) Quantification of liver (n = 12 per group) and pancreas (n = 6 per group) iron levels in Hepc−/−Hif-2αΔint (●) and Hepc−/− (■) versus CTR (▴) mice. (B) Perls' blue staining of the liver, pancreas, and spleen of CTR, Hepc−/−, and Hepc−/−Hif-2αΔint mice. One representative picture of each genotype is shown. Bars represent 200 μm. (10×/0.45, Nikon E800 microscope, CDD QICAM cooled camera [QImaging, QCapture Version 2.98.2 software [Qualitative Imaging Corporation]). (C) Plasma ferritin, plasma iron, and transferrin saturation in Hepc−/−Hif-2αΔint (▴; n = 9) versus Hepc−/− (■; n = 9) and CTR (● n = 9) mice. ***P < .001. ns indicates not significant.

Iron parameters are decreased in the Hepc−/−Hif-2αΔint mice compared with Hepc−/− mice. (A) Quantification of liver (n = 12 per group) and pancreas (n = 6 per group) iron levels in Hepc−/−Hif-2αΔint (●) and Hepc−/− (■) versus CTR (▴) mice. (B) Perls' blue staining of the liver, pancreas, and spleen of CTR, Hepc−/−, and Hepc−/−Hif-2αΔint mice. One representative picture of each genotype is shown. Bars represent 200 μm. (10×/0.45, Nikon E800 microscope, CDD QICAM cooled camera [QImaging, QCapture Version 2.98.2 software [Qualitative Imaging Corporation]). (C) Plasma ferritin, plasma iron, and transferrin saturation in Hepc−/−Hif-2αΔint (▴; n = 9) versus Hepc−/− (■; n = 9) and CTR (● n = 9) mice. ***P < .001. ns indicates not significant.

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