Platelet transporters and their proposed functions at a glance. Platelets express a variety of SLC and ABC transporters, which are located in the plasma membrane as well as in the membranes of intracellular compartments,such as the dense (δ) and α (α) granules, and in other intracellular membrane systems, such as the dense tubular system (DTS; for details and references, see Table 1). They play a vital role in the uptake, sequestration, and release of mediators involved in platelet function. With respect to pharmacotherapy, the platelet represents a pharmacokinetic microcompartment, in which the interplay between uptake and elimination transporters determines intracellular drug concentrations.