Disease-free survival by donor availability with the hazard ratio (HR) plots for study group, risk, and age subgroups. The percentage reduction is equal to 100 × (1 minus] HR). Patients without cytogenetic information are not included in a cytogenetic risk subgroup. The not-favorable cytogenetic group consists of all patients lacking favorable cytogenetic abnormalities. Within that group several subgroups are considered. All patients not classified as favorable or unfavorable were considered intermediate risk. Normal, −Y is a subgroup of the intermediate group and contains all patients without cytogenetic abnormalities or with only −Y, as was derived from the EORTC, BGMT, and HOVON series. The unfavorable group includes all patients classified as bad or very bad in the EORTC series or as unfavorable in the other studies (MRC, HOVON-SAKK, BGMT). The pooled estimate of the HR of donor availability for DFS for all patients irrespective of age or cytogenetic subgroup is 0.79 (95% CI, 0.72-0.88; P < .001).