Linear combination of marker probe sets. (A) Unsupervised linear combination of expression of the 18 subjects over 4 time points after BCR crosslinking. Eight hundred sixty of 54 675 probe sets satisfied the filtering criteria. (B) Probe sets differentially expressed over time between UM-CLL Zap+ B cells and M-CLL Zap− B cells. One hundred eighteen of 54 675 probe sets satisfied the filtering criteria. (C) Probe sets differentially expressed over time between healthy B cells and CLL patient marker genes. One hundred four of 54 675 probe sets satisfied the filtering criteria.