FTY720 simultaneously inhibits their emigration from the parathymic lymph nodes and their entrance from the blood into the PerC. SCID mice were adoptively transferred with CFSE-labeled normal PerC B cells via the intraperitoneal (A) or the intravenous (B) route, and simultaneously treated with (• or bottom panels) or without (○ or top panels) FTY720. After 12 hours, cells were isolated from the PerC, blood, omentum, parathymic lymph nodes, and bone marrow for the analysis of CFSE⁺ cells. Horizontal bars represent the mean.