Fondaparinux for treatment of acute HIT: studies including 5 or more patients with putative HIT (with or without HIT-associated thrombosis)
A PubMed search performed on April 23, 2011 using “fondaparinux” and “heparin-induced thrombocytopenia” had 152 “hits,” from which 3 studies31–33 of non-critically ill patients were identified that described the use of fondaparinux for 5 or more cases of acute HIT. Also included is one study by the author.34
*The single patient without thrombosis received 2.5 mg daily by subcutaneous injection.
†One patient with popliteal artery thrombosis and failed thrombectomy required amputation; however, irreversible ischemic limb necrosis was judged to have been present before fondaparinux therapy.
‡One patient had limb amputation before commencing fondaparinux.
§Dosing ranged from 2.5-15 mg/d (7.5 mg was the median daily dose).
¶One patient with brachial artery thrombosis and failed thrombectomy required amputation; however, irreversible ischemic limb necrosis was judged to have been present before fondaparinux therapy.
