*Reports of insufficient liver iron removal in some patients at doses of 75 mg/kg/d, but higher dosing, especially for subjects with high transfusional iron burden, may be more effective

†With continuous infusion.

‡Limited data show cardiac iron removal with modest cardiac iron loading; may be less effective in patients with more severe hepatic iron loading. Further studies are needed to determine effectiveness at cardiac iron removal compared with deferoxamine and deferiprone.

§Not studied in patients with cardiac dysfunction. Lack of improvement in ejection fraction with deferasirox treatment (for 1-2 years) in patients with normal cardiac function.

¶More common in patients with advanced age, high-risk myelodysplastic syndrome, underlying hepatic or renal insufficiency, and/or cytopenias.