Table 1.
Current diagnostic criteria for JMML
*Current WHO criteria.
†Proposed additions to the WHO criteria that were discussed by participants attending the JMML Symposium in Atlanta, GA, 2008.41 Note that CBL mutations have since been discovered and should be screened for in the workup of a patient with suspected JMML. Patients who are found to have a category 2 lesion need to meet criteria in category 1, but do not need to meet category 3 criteria. Patients who are not found to have a category 2 lesion must meet the category 1 and 3 criteria. Only 7% of patients with JMML will NOT present with splenomegaly, but virtually all patients develop this within several weeks to months of initial presentation (Niemeyer, personal communication).
