Figure 4
Figure 4. Increased STAT-3 phosphorylation in PLNs and spleen of vIL-6tg2 mice. (A) Western blot for STAT3 tyrosine-705 phosphorylation (P-STAT3) and total STAT3 in PLN and spleen tissue from 4 wild-type and 4 vIL-6tg2 mice (15 weeks old). Lysates from vIL-6tg2 tissues were loaded according to increasing weight for the PLN (inguinal nodes combined; wt, 5.3-7.1 mg; vIL-6tg2, 9.2-38.9 mg) and spleen (wt, 60.9-78.8 mg; vIL-6tg2, 76.8-166.2 mg). Ratio of P-STAT3 to total STAT3 band intensities is given. (B) IHC for P-STAT3 of 21-week-old wild-type (i,iii) and vIL-6tg2 (ii,iv) lymph node (i-ii) and spleen (iii-iv; 10-fold magnification).

Increased STAT-3 phosphorylation in PLNs and spleen of vIL-6tg2 mice. (A) Western blot for STAT3 tyrosine-705 phosphorylation (P-STAT3) and total STAT3 in PLN and spleen tissue from 4 wild-type and 4 vIL-6tg2 mice (15 weeks old). Lysates from vIL-6tg2 tissues were loaded according to increasing weight for the PLN (inguinal nodes combined; wt, 5.3-7.1 mg; vIL-6tg2, 9.2-38.9 mg) and spleen (wt, 60.9-78.8 mg; vIL-6tg2, 76.8-166.2 mg). Ratio of P-STAT3 to total STAT3 band intensities is given. (B) IHC for P-STAT3 of 21-week-old wild-type (i,iii) and vIL-6tg2 (ii,iv) lymph node (i-ii) and spleen (iii-iv; 10-fold magnification).

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