Scheme illustrating a normal blood vessel (A), the abnormalities of a tumor blood vessel (B), and a partially normalized tumor blood vessel (C). BM indicates basement membrane; phalanx ECs, quiescent ECs; IFP, interstitial fluid pressure; PC, pericytes; M1-TAM, M1-polarized tumor-associated macrophages. (Reprinted with permission from Carmeliet and Jain.²⁶ )