DNA methylation segregates AML patients into 16 groups. Heatmap representation of a correlation matrix in which each patient's DNA methylation profile is correlated with that of the other patients in the data set. Patients are ordered according to the unsupervised analysis (hierarchical clustering) results, so that highly correlated patients are located next to each other. Parallel bars on the right of the heatmap have been used to indicate the principal cytogenetic and molecular findings for each patient. Cluster membership and cluster feature summaries are described on the left-hand side of the heatmap. Reprinted with permission from Cancer Cell.⁴⁸