Molecular heterogeneity of CN-AML based on mutations in the NPM1, CEBPA, MLL, FLT3 (ITD and TKD mutations at codons D835 and I836), NRAS, and WT1 genes. Blue colors denote NPM1-mutated subsets, orange/red colors denote CEBPA-mutated subsets, and yellow/green colors denote MLL-mutated subsets. Gray colors depict subsets without hypothetical class II mutations, and the white sector shows the subset without any mutation in the previously described genes. Data are derived from mutational analysis of 485 younger adult patients with CN-AML from the German AML Study Group. Reprinted with permission from Blood.¹⁰