√, organ commonly involved; [√], organ uncommonly involved; AApoAI, mutant apoliprotein A-I amyloidosis; AFib, mutant fibrinogen A-α amyloidosis; AGel, mutant gelsolin amyloidosis; ALys, mutant lysozyme amyloidosis; ATTRm, mutant transthyretin amyloidosis; ATTRwt, wild-type transthyretin amyloidosis; PNS, peripheral nervous system; ST, soft tissues.

*The current nomenclature of amyloidosis is based on the nature of the major fibrillar protein that is designated protein A, followed by an abbreviation of the protein's name. The protein must be a major fibril protein in extracellular deposits with affinity for Congo red with apple-green birefringence.

^†Monoclonal gammopathies are two times more common in African Americans than in Caucasians.

^‡V122I ATTRm occurs in 4% of African Americans.