Figure 2
Figure 2. Structure of various HCD proteins compared with that of the corresponding normal chain. Shown are the HCD proteins for which the complete sequence is known. V indicates variable region; D, diversity segment; J, joining region; H, hinge region; and CH1, CH2, CH3, and CH4, constant regions of heavy chains. Light turquoise indicates sequences derived from variable region; turquoise, sequences derived from CH domains or hinge region; hashed boxes, sequences derived from D or J segments; purple, unusual amino acid sequences; and dark turquoise, amino acids of the membrane-bound form of HC. Adapted from Buxbaum and Alexander.7 Note that α1SEC exists only in the membrane form.

Structure of various HCD proteins compared with that of the corresponding normal chain. Shown are the HCD proteins for which the complete sequence is known. V indicates variable region; D, diversity segment; J, joining region; H, hinge region; and CH1, CH2, CH3, and CH4, constant regions of heavy chains. Light turquoise indicates sequences derived from variable region; turquoise, sequences derived from CH domains or hinge region; hashed boxes, sequences derived from D or J segments; purple, unusual amino acid sequences; and dark turquoise, amino acids of the membrane-bound form of HC. Adapted from Buxbaum and Alexander.7  Note that α1SEC exists only in the membrane form.

Close Modal
This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal