Schematic depiction of myelo-erythroid regulation of MPCs in the ICM. During normal primitive hematopoiesis, MPCs in the ICM predominantly differentiate into erythrocytes together with a few myelocytes (left). In SUMO-deficient embryos, there is an increased myelopoiesis of MPCs mediated by augmented transcriptional activity of desumoylated C/ebpα and its inhibition effect over Gata1 (right).