Inhibitor studies in pIR8.5/F8null mice. FeCl₃ carotid artery injury studies in hF8.38/F8^null mice (gray bars), and pIR8.5/F8^null mice (black bars). In panels A and B on the left is an acute study where the animals received a one time infusion of the inhibitor mix, and in the middle are chronic studies done on day 10 of study after a murine IgG control or murine inhibitor mix infusions of F8 on days 0, 3, 6 and 9. On the right are chronic studies done using inhibitor IgG purified from F8-deficient plasma. In panels A and B, mean ± 1 SD are shown for N < 5 mice per arm. Results in panel A are expressed as average blood flow seen. Studies in panel B show the time to occlusion. *P < .025 and **P < .05 relative to phF8.38. Gray horizontal bars in panels A and B indicate the mean ± 1 SD for WT (bottom) and F8^null (top) mice.