PRC1 and PRC2 do not synergize in HSC/progenitor function. (A) Peripheral blood platelet (top panel) and white blood cell counts (bottom panel) at 7 weeks of age from mice of the given genotypes, all additionally Mpl^−/−. The horizontal bar marks the mean for n = 40 samples per genotype. (B) Bone marrow cells from 6 to 9 Mpl^−/−CD45^Ly5.2 donor mice of the given genotype were mixed 1:1 with wild-type Mpl^−/−CD45^Ly5.1 competitor cells and used to reconstitute 3 lethally irradiated recipients per donor. Contribution of test cells to each hematopoietic organ is shown 10 to 16 weeks after reconstitution. Blood indicates peripheral white blood cells. Statistical significance *P < .05, **P < .01, ***P < .001, corrected for multiple testing; error bars indicate SEM.