PPIC and serum D-dimer levels before and 1, 2, 4, 6, and 24 hours after administration of the endotoxin. Results are shown as medians and interquartile ranges for patients with FVL (●) and controls (□). Patients with FVL display a more sustained generation of PPIC after endotoxin infusion. Highest levels of D-dimer in serum are observed 2 hours after endotoxin infusion. Inserts in panel A show the distribution of the 6-hour values for patients with FVL and controls (N).