Flow chart showing the presence and type of ACAs in 756 pediatric patients with 11q23/MLL-rearranged AML. Complete karyotypes were not available for 23 patients, and they were therefore excluded from analyses. The presence or absence of ACAs was determined for 733 patients for whom complete karyotypes were available. In the cohort having ACAs balanced karyotype was coded for 25 patients; the remaining had an unbalanced karyotype. The types of aberrations were coded as numerical, structural, or both, and the number of aberrations was also coded. Losses and gains are further coded in other figures.