Up-regulation of oncogenes near integrants cloned from tumor tissue occurs independently of vector integration. Expression analysis of up-regulated (A) mouse cancer-related genes and (B) mouse homologs of human cancer-related genes located within 100 kb of an AAV2-hFIX16 integrant cloned from tumor tissue. Expression ratio was obtained by dividing the absolute array signal from tumor tissue by the absolute array signal from adjacent normal tissue. Individual M24 and M50 Ntrk1 integrants were quantified by qPCR, performing 4 independent measurements on total DNA isolated from tumor tissue.