The effect of NF-κB inhibition on HTLV-I proviral load. PBMCs from subjects with HAM/TSP were placed in culture, and serial HTLV-I proviral loads were measured by real-time polymerase chain reaction. (A) The mean (±standard deviation [SD]) HTLV-I proviral load in untreated PBMCs from subjects with HAM/TSP measured at the indicated time points in culture (n = 3; P = .0174, Friedman test). (B) The mean (±SD) HTLV-I proviral load in untreated, DMSO (vehicle)–, DHMEQ (10μM)–, or PBS-1086 (10μM)–treated HAM/TSP PBMCs (n = 3).