Platelet depletion, platelet inhibition, or antithrombotic therapy prevented death or prolonged survival times in the ThCD59^RBC mice treated with ILY₁₄₀FI. The mortality rates (A), sP-selectin levels (B), platelet counts (C), lung P-selectin (D), and integrin αIIb staining (E) in the ThCD59^RBC mice pretreated with the different antithrombotic agents before ILY₁₄₀FI treatment. The WT mice treated with ILY₁₄₀FI were used as the control for sP-selectin and integrin αIIb staining and platelet counts. *P < .05 vs ThCD59^RBC without drug pretreatment.