Figure 5
Figure 5. Representative images of integrin αIIb and P-selectin staining in lung. There is more extensive integrin αIIb and P-selectin staining (arrows) in small perialveolar blood vessels in the lungs of ThCD59RBC mice treated with ILY140FI than in those treated with ILY140SI. Platelet aggregates were adherent to the vessel walls in the ThCD59RBC mice treated with ILY140FI; this is evident in the 60× magnified images. WT mouse lungs had no or very little staining. Lower magnification (4× and 10×) images for P-selectin staining of the different mice are shown in supplemental Figure 3.

Representative images of integrin αIIb and P-selectin staining in lung. There is more extensive integrin αIIb and P-selectin staining (arrows) in small perialveolar blood vessels in the lungs of ThCD59RBC mice treated with ILY140FI than in those treated with ILY140SI. Platelet aggregates were adherent to the vessel walls in the ThCD59RBC mice treated with ILY140FI; this is evident in the 60× magnified images. WT mouse lungs had no or very little staining. Lower magnification (4× and 10×) images for P-selectin staining of the different mice are shown in supplemental Figure 3.

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