American Society of Hematology

Figure 2

ILY140FI-induced death in ThCD59RBC mice associated with a significantly lower RRRVSP compared with ILY140SI or ILY70FI. (A-D) Representative tracings show the dynamic changes in RVSP in the WT (A) and ThCD59RBC mice with ILY140FI (B), and the ThCD59RBC mice with ILY140SI (C) and ILY70FI (D). (E) RRRVSP comparison among these mice. RRRVSP (mm Hg/s) = increased systolic pulmonary arterial pressure (in mm Hg)/time (in seconds; black line in panel B). RRRVSP t test. *P < .05 vs ThCD59RBC mice with ILY140FI. Results represent mean ± SEM.

ILY₁₄₀FI-induced death in ThCD59^RBC mice associated with a significantly lower RRRVSP compared with ILY₁₄₀SI or ILY₇₀FI. (A-D) Representative tracings show the dynamic changes in RVSP in the WT (A) and ThCD59^RBC mice with ILY₁₄₀FI (B), and the ThCD59^RBC mice with ILY₁₄₀SI (C) and ILY₇₀FI (D). (E) RRRVSP comparison among these mice. RRRVSP (mm Hg/s) = increased systolic pulmonary arterial pressure (in mm Hg)/time (in seconds; black line in panel B). RRRVSP t test. *P < .05 vs ThCD59^RBC mice with ILY₁₄₀FI. Results represent mean ± SEM.

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