Tumor necrosis factor α network is key epigenetically dysregulated network between ABC and GCB DLBCLs. Integration of 263 differentially methylated genes with 622 differentially expressed genes allowed identification of one main differentially regulated network with the use of Ingenuity Pathway Analysis software: Tumor Necrosis Factor α Pathway. Relative expression and methylation is represented by the ratio of ABC to GCB: overmethylated genes have greater methylation in ABC than in GCB DLBCLs, and overexpressed genes have greater expression in ABC than in GCB DLBCLs.