Mean bleeding duration before and after warfarin and trial product (rFVIIa or placebo) treatments for subjects in experiment 2. B0 indicates biopsy 0 (before warfarin treatment); B1, biopsy 1 (after warfarin treatment to achiever INR of 2.5 ± 0.3); B2, biopsy 2 (15 minutes after rFVIIa or placebo treatment); B3, biopsy 3 (5 hours after B2). Dashed arrow indicates time of rFVIIa administration. The model used was a generalized linear model with logarithmic link and γ distribution, and bleeding duration at B1 as a covariate. Mean values for B0 and B1 were geometric means, and mean values for B2 and B3 were least-square means derived from the generalized linear model.