Podoplanin-Fc induces disseminated intravascular coagulation, leading to thrombocyte consumption and bleeding diathesis. (A) A transgenic mouse was examined postmortem after spontaneous death and compared with a wild-type littermate at an age of 26 days. Melena, pale liver, and serosa suggest bleeding to the intestine. (B-C) Embolized blood vessels were observed on cryosections of intestine (B) and other organs (C) of transgenic mice, immunohistochemically stained for human podoplanin. (D) Times until the cessation of bleeding after tail clipping of wild-type and transgenic mice were measured. *** P < .001. (E) Thrombocyte counts in the blood of wild-type and transgenic mice were determined. Bars represent 100 μm (B) and 25 μm (C). wt wild-type; tg transgenic.