Frequencies of CNAs. (A) Frequencies of copy number alterations (CNAs) in the first available biopsies from all 44 patients. The biopsies were obtained before any treatment in 28 of the patients and at relapse in 16 of the patients. (B) Frequencies of CNAs in the first (light blue bars) and the last (dark blue line) examined biopsies of follicular lymphoma (FL; grade 1, 2, or 3a) from 35 patients. (C) Frequencies of CNAs in the first examined biopsy of FL from 17 cases that did not undergo transformation (light blue bars) and 27 cases that underwent transformation (red lines). (D) Frequencies of CNAs in all biopsies with histologic grades FL1/FL2 (blue bars; n = 74) and in all biopsies with FL grade 3a (orange line; n = 17).