Deletion of the TF gene in ECs or VSMCs has no effect on activation of coagulation. (A) Plasma TAT levels were analyzed 8 hours after LPS injection in TF^flox/flox transplanted with TF^flox/flox bone marrow (n = 18, mean ± SEM 35.9 ± 2.3 ng/mL), TF^flox/flox transplanted with TF^flox/flox,Tie-2^Cre bone marrow (n = 12, mean ± SEM 22.7 ± 2.3 ng/mL), TF^flox/flox,Tie-2^Cre transplanted with TF^flox/flox bone marrow (n = 13, mean ± SEM 34.1 ± 2.5 ng/mL) and TF^flox/flox,Tie-2^Cre transplanted with TF^flox/flox,Tie-2^Cre bone marrow (n = 13, mean ± SEM 23.4 ± 2.6 ng/mL). (B) Plasma TAT levels were analyzed 8 hours after LPS injection in TF^flox/flox (n = 17; mean ± SEM 24.5 ± 3.5 ng/mL) and TF^flox/flox,SM22^Cre (n = 19; mean ± SEM 22.9 ± 3.4 ng/mL). In panel A the presence or absence of Cre recombinase in recipient and donor mice is indicated by Cre+ and Cre−. *P < .05 compared with control group expressing normal levels of TF (first bar in panel A).