Figure 1
CD40 mutations causing HIGM. Structural model of the CD40 extracellular domain (amino acid 26 to 157) showing the positions of the P2, P4, and P5 mutations (solid black arrows) and the position of 1 of the 2 N-glycosylation sites (orange box). The cysteine residues and the conserved disulphide bridges are shown in blue.

CD40 mutations causing HIGM. Structural model of the CD40 extracellular domain (amino acid 26 to 157) showing the positions of the P2, P4, and P5 mutations (solid black arrows) and the position of 1 of the 2 N-glycosylation sites (orange box). The cysteine residues and the conserved disulphide bridges are shown in blue.

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