Figure 4
Inflammation-mediated myeloid cell recruitment and macrophage-mediated wound healing are unaffected by anti-CSF1R treatment. (A) Anti-CSF1R and rat IgG mAb-treated MacGreen mice were administered thioglycollate broth and cells within the peritoneal cavity collected by lavage 5 days later. Cells were counted, and 2-color flow cytometry was used to enumerate monocyte and granulocyte numbers. (B) BAL fluid was collected 24 and 48 hours after intratracheal instillation of LPS in anti-CSF1R and rat IgG mAb-treated MacGreen mice. Cells were counted, and 2-color flow cytometry was used to enumerate monocyte and granulocyte numbers. (C) Polidocanol detergent was used to strip the epithelial lining from one side of the nasal septum, with the contralateral side used as a control. Image shows nasal septum from anti-CSF1R and rat IgG-treated animals 9 days after polidocanol administration. Bar represents 200 μm.

Inflammation-mediated myeloid cell recruitment and macrophage-mediated wound healing are unaffected by anti-CSF1R treatment. (A) Anti-CSF1R and rat IgG mAb-treated MacGreen mice were administered thioglycollate broth and cells within the peritoneal cavity collected by lavage 5 days later. Cells were counted, and 2-color flow cytometry was used to enumerate monocyte and granulocyte numbers. (B) BAL fluid was collected 24 and 48 hours after intratracheal instillation of LPS in anti-CSF1R and rat IgG mAb-treated MacGreen mice. Cells were counted, and 2-color flow cytometry was used to enumerate monocyte and granulocyte numbers. (C) Polidocanol detergent was used to strip the epithelial lining from one side of the nasal septum, with the contralateral side used as a control. Image shows nasal septum from anti-CSF1R and rat IgG-treated animals 9 days after polidocanol administration. Bar represents 200 μm.

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