Figure 4
![Figure 4. Platelet CD40L promotes atherosclerosis initiation. (A) Plaque area of the aortic arch, including the main branch points (brachiocephalic trunk [BCT], left common carotid artery [LCC], left subclavian artery) of Apoe−/− mice, injected every 5 days for 12 weeks with activated Cd40l+/+Apoe−/− or Cd40l−/−Apoe−/− platelets, or vehicle (n = 11/group). (B-D) Representative longitudinal sections (hematoxylin and eosin staining) of the aortic arch and main branch points. Note the early, foam cell-rich atherosclerotic lesions formed in the brachiocephalic trunk. Scale bar represents 200 μm. (E) Plaque area in the aortic root of the same mice (n = 9/group). *P < .05.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/116/20/10.1182_blood-2010-01-261206/7/zh89991060620004.jpeg?Expires=1724256855&Signature=hmWwdM5ZF3WL-8FRGRbtcBGmWCStY-lK4DSc5ohkweOa4Qh9WdBeqbZo7qM4h8LF28WiYwWRt3vEaJzLz5Cq0CkdCRLhemx3GCvbPrXiKv7zkNK4UrO0oVwM-nugm7JNkg3wZ7NLgIasiTA-JHpQv3iiHth9TE3MVUbVO7Pd5J~YFZ258X2Wb9NP3-wpqALM2iKeC3t2fic-2qMgbgcLxmdz~7WOUWgd-Q8zsrCdREB0sHxzBd1S6E9yl9JJt5X8-L2~sLeva~Tde8H5bqXpakxqdemeOo39~XmXK2XYLsUGD~cFufIH1yipgHjx9Xp8ElKZJG5oD7LXE-DBv-jaBg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Platelet CD40L promotes atherosclerosis initiation. (A) Plaque area of the aortic arch, including the main branch points (brachiocephalic trunk [BCT], left common carotid artery [LCC], left subclavian artery) of Apoe−/− mice, injected every 5 days for 12 weeks with activated Cd40l+/+Apoe−/− or Cd40l−/−Apoe−/− platelets, or vehicle (n = 11/group). (B-D) Representative longitudinal sections (hematoxylin and eosin staining) of the aortic arch and main branch points. Note the early, foam cell-rich atherosclerotic lesions formed in the brachiocephalic trunk. Scale bar represents 200 μm. (E) Plaque area in the aortic root of the same mice (n = 9/group). *P < .05.
