Surrogate cell reproducibility. Data represent replicate of experiments for a single subject with EA.hy926 and LPS-THP-1 conducted on 2 occasions (▴, ▵) with an 8-day interval between experiments. These data illustrate the reproducibility of (A) TAT formation, (B) FPA formation, (C) fV activation, and (D) fVa inactivation in these duplicate experiments. These data show the reproducibility of the method with respect to the use of the 2 surrogates and also show these observations for the single subject are representative of those for the cohort.