Figure 4
In vitro T-ALL growth is inhibited by γ-secretase inhibitors. (A) Day 30 amplification rate of M18 and M30 T-ALL leukemic cells cocultured with MS5-GFP and MS5-DL1 in presence (+GSI) or in absence (−GSI) of γ-secretase inhibitor. Shown are mean plus or minus SD of 3 (M18) and 4 (M30) experiments. (B) mRNA levels of pTα, HES1, and deltex measured on day 3 of culture of M18 and M30 cells. Shown are mean values plus or minus SD of 4 measurements normalized using β2-microglobulin mRNA levels. Data are expressed as percentage of b2m values. *P < .05; **P < .01; ***P < .001; NS, not significant.
