Figure 7
Figure 7. NK cells maintain GVT response to A20. (A) Ventral BLI images of animals that received a transplant of TCD-BM plus A20-luc+/yfp, A20-luc+/yfp plus Tcons, or A20-luc+/yfp plus Tcons and NK cells. Both Tcon and Tcon + NK groups reject the tumor within 2 weeks after transplantation. (B) Quantification of BLI images from panel A. Compared with A20 controls, Tcon and Tcon + NK groups have significantly lower BLI signal. NK cells alone provide some antitumor capability but fail to clear the tumor. (C) BLI quantification shown without the A20 control. TCD-BM–only recipients are shown as controls. Tcons + NK have significantly lower BLI at day 4 after T-cell transplantation (P < .05). Data points are average BLI from 4 to 5 mice, and are representative of 2 experiments. Error bars represent SE.

NK cells maintain GVT response to A20. (A) Ventral BLI images of animals that received a transplant of TCD-BM plus A20-luc+/yfp, A20-luc+/yfp plus Tcons, or A20-luc+/yfp plus Tcons and NK cells. Both Tcon and Tcon + NK groups reject the tumor within 2 weeks after transplantation. (B) Quantification of BLI images from panel A. Compared with A20 controls, Tcon and Tcon + NK groups have significantly lower BLI signal. NK cells alone provide some antitumor capability but fail to clear the tumor. (C) BLI quantification shown without the A20 control. TCD-BM–only recipients are shown as controls. Tcons + NK have significantly lower BLI at day 4 after T-cell transplantation (P < .05). Data points are average BLI from 4 to 5 mice, and are representative of 2 experiments. Error bars represent SE.

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