Supervised hierarchical clustering of methylated/unmethylated genes between CLL subgroups. Three different comparisons were made: (A) IGHV mutated (samples M1 to M6) versus IGHV unmutated (samples UM1 to UM7), (B) IGHV unmutated versus IGHV3-21 (samples 3-21-1 to 3-21-10), and (C) IGHV mutated versus IGHV3-21. Two normal healthy control samples and 1 negative control were included for comparison. A gradient color scale ranging between green (completely unmethylated) and red (completely methylated) is included.