Gfi1 integrates separable transcriptional programs in myeloid progenitors. Graphic representations. (A) In CMPs, HoxA9 is autoregulated. (B) In GMPs, Gfi1 represses Meis1, Pbx1, and HoxA9. Deregulation of Gfi1 leads to the HoxA9-dependent accumulation of myeloid progenitors. (C) Granulopoiesis is critically controlled by Gfi1 repression of target genes such as Csf1 and Egr2.^20,47