Loss of IFNα/βR protein expression at the cell surface is not explained by diminished IFNα/βR mRNA. RNA was extracted from purified monocytes from uninfected and HIV-1–infected persons ex vivo, and mRNA for IFNAR1 and IFNAR2 (both chains of the IFNα/βR) was quantified by qRT-PCR and normalized to GAPDH. Cell-surface IFNα/βR expression, as determined by flow cytometry, did not correlate with mRNA for IFNAR1 (r = 0.048, P = .866) or IFNAR2 (r = 0.074, P = .793).