miR-34a expression and p53 pathway activity in CLL. Deletion (17p13) or mutation of TP53, deletion (11q22−) or mutation of ATM, and increased MDM2 activity (SNP309 GG) impair p53 pathway function in CLL, resulting in decreased expression of miR-34a.
miR-34a expression and p53 pathway activity in CLL. Deletion (17p13) or mutation of TP53, deletion (11q22−) or mutation of ATM, and increased MDM2 activity (SNP309 GG) impair p53 pathway function in CLL, resulting in decreased expression of miR-34a.
